08.30-08.50h Registration
08.50-09.00h Welcome
Elias Campo and Maria Rozman, Barcelona (Spain)
09.00-12.30h BASIC COURSE:
Interactive case-based basic approach to BM pathology

Chairs: Alexandar Tzankov, Basel (Switzerland) and María Rozman, Barcelona (Spain)
09.00-09.30h Proliferation
Agustín Acevedo, Madrid (Spain)
09.30-10.00h Dysplasia
Hans Michael Kvasnicka, Wuppertal (Germany)
10.00-10.30h Blasts
Daniel Arber, Chicago (USA)
10.30-11.00h Coffee
11.00-11.30h Eosinophilia
Sa Wang, Houston (USA)
11.30-12.00h Cytopenia
Margarita Elices, Madrid (Spain)
12.00-12.30h Lymphoid infiltrates
Leticia Quintanilla-Martinez de Fend, Tubingen (Germany)
12.30-14.00h Lunch
Chairs: Roos Leguit, Utrecht (Netherlands) and Sa Wang, Houston (USA)
14.00-14.30h Systemic mastocytosis with an associated myeloid neoplasm
Attilio Orazi, El Paso (USA)
14.30-15.00h Immunophenotypic and molecular characterization of mastocytosis
and mast cell activation syndromes: impact on the diagnosis and
classification of systemic mastocytosis

Alberto Orfao, Salamanca (Spain)
15.00-15.30h Update on recent advances in the clinical management of patients
with advanced systemic mastocytosis

Andreas Reiter, Mannheim (Germany)
15.30-16.00h Coffee
16.00-18.00h WORKSHOP 1
Systemic mastocytosis with an associated myeloid neoplasm

Chairs: Attilio Orazi, El Paso (USA) and Roos Leguit, Utrecht (Netherlands)

SM-44 – A 66-year-old man with malaise, sweating and splenomegaly
José Tomás Navarro, Barcelona (Spain)

SM-29 – Aggresive systemic mastocytosis with an associated myelomonocytic leukemia: the role of genetics in disease progression
Carlo Pescia, Milan (Italy)

SM-47 – Systemic mastocytosis and T-lymphoblastic lymphoma with unifying cryptic PDGFRB rearrangement
Kevin Shopsowitz, Columbia (Canada)

SM-78 – Systemic mastocytosis associated with blastic plasmacytoid dendritic cell neoplasm
Nana Matsumolo, Boston (USA)

SM-117 – A 64-year-old man with systemic mastocytosis with associated mixed-phenotype acute leukemia (Mye/T)
Krasimira Rozenova, New York (USA)

Session summary by the chairs

09.00-10.00h MYELOID NEOPLASMS (1)
Chairs: Hans Michael Kvasnicka, Wuppertal (Germany) and Agustín Acevedo, Madrid (Spain)
09.00-09.30h Keynote lecture. Bone marrow niches in hematological malignancies
Simón Méndez-Ferrer, Cambridge (United Kingdom)
09.30-10.00h Triple negative myelofibrosis: a diagnostic challenge
Alberto Álvarez-Larrán, Barcelona (Spain)
10.00-10.30h Coffee
10.30-12.30h WORKSHOP 2: part 1
Myeloproliferative neoplasms, myelodysplastic/myeloproliferative neoplasms, myelodysplastic syndromes with genetic alterations that impact in their classification

Chairs: Hans Michael Kvasnicka, Wuppertal (Germany) and Maria Rozman, Barcelona (Spain)

MPN-21 – Concamitant bone marrow involvement by chronic myeloid leukemia and polycythemia vera
April Chiu, Rochester  (USA)

MPN-45 – Mast cell proliferation with morphological features resembling systemic mastocytosis in a case of myeloid/lymphoid neoplasm with eosinophilia (M/LN-Eo) and tyrosine kinase gene fusions (FIP1L1::PDGFRA rearrangement)
Rafaella Santi, Florence (Italy)

MPN-70 – Unique evolution after AML with mutated NPM1
Sandra Castaño, Barcelona (Spain)

SM-105 – An unusual JAK2 variant detected in a suspected case of polycythaemia vera, could this be a potential myeloproliferative neoplasm dianostic unknown deriver mutation?
Samah Kohla, Doha (Qatar)

MPN-119 – Multi-hit TET2 and SRSF2 mutation support a diagnosis of chronic myelomonocytic leukemia with fibrosis associated with JAK2 V617F mutation rather than PMF with monocytosis
Osvaldo Padilla, El Paso (USA)

Session summary by the chairs

12.30-14.00h Lunch
14.00-15.30h MYELOID NEOPLASMS (2)
Chairs: Daniel Arber, Chicago (USA) and Attilio Orazi, El Paso (USA)
14.00-14.30h Updates in the diagnosis of myelodysplastic syndromes
Rob Hasserjian, Boston (USA)
14.30-15.00h Molecular international prognosis scoring system for myelodysplastic syndromes
Francesc Solé, Barcelona (Spain)
15.00-15.30h Oligomonocytic Chronic Myelomonocytic Leukemia (OM-CMML) and other updates in MDS/MPN
Xavier Calvo, Barcelona (Spain)
15.30-16.00h Coffee
16.00-18.00h WORKSHOP 2: part 2
Myeloproliferative neoplasms, myelodysplastic/myeloproliferative neoplasms, myelodysplastic syndromes with genetic alterations that impact in their classification

Chairs: Rob Hasserjian, Boston (USA) and Leonor Arenillas, Barcelona (Spain)

MPN-8 – Myelodysplastics neoplasm with biallelic TP53 inactivation vs. acute erythroid leukaemia
Giovanni Martino, Perugia  (Italy)

MPN-13 – Myeloid neoplasm with isolated del(5q) and JAK2 V617F mutation
Saverio Pancetti, Rozzno (Italy)

MPN-42 – A patient with germline SAMD9L variant showing dynamic clonal hematopoiesis as part of somatic rescue: a disappearing -7 clone and subsequent clones with somatic SAMD9L mutations
Yen-Chun Liu, Pittsburgh (USA)

MPN-51 – Acute myeloid leukaemia with two recurrent genetic abnormalities: NPM1 mutation and BCR::ABL1 fusion gene
Andrea Espasa, Barcelona (Spain)

MPN-77 – Diagnosis of myelodysplastic syndrome with discovery of UBA1 mutation: Clarifying the contribution of the myeloid disorder to a complex clinical picture
Genevieve Crane, Cleveland (USA)

Session summary by the chairs

21.00h Social dinner

Chairs: Leticia Quintanilla- Martinez de Fend, Tubingen (Germany) and Maurilio Ponzoni, Milan (Italy)
09.00-09.30h Lymphoplasmacytic Lymphoma
Santiago Montes-Moreno, Santander (Spain)
09.30-10.00h Plasma cell neoplasms and related disorders, what’s new?
Falko Fend, Tübingen (Germany)
10.00-10.30h Clinical features and therapeutic approach for malignant monoclonal gammopathies (multiple myeloma and Waldenström macroglobulinemia / lymphoplasmacytic lymphoma)
Carlos Fernández de Larrea, Barcelona (Spain)
10.30-11.00h Coffee
Chairs: Fina Climent, Barcelona (Spain) and Falko Fend, Tubingen (Germany)
11.00-11.30h Keynote lecture. Molecular genetics of Chronic lymphocytic leukemia
Elias Campo, Barcelona (Spain)
11.30-12.00h T-cell lymphomas in the bone marrow: primary ones and such that spread therein
Alexandar Tzankov, Basel (Switzerland)
12.00-12.30h The role of PET vs bone marrow biopsy for the staging of the lymphomas
Armando Lopez-Guillermo, Barcelona (Spain)
12.30-14.00h Lunch
Chairs: Armando López-Guillermo, Bacelona (Spain) and Santiago Montes-Moreno, Santander (Spain)
14.00-14.30h Hairy cell leukemia genetics: biological and clinical implications
Enrico Tiacci, Perugia (Italy)
14.30-15.00h Splenic marginal zone lymphoma: lights and shadows
Maurilio Ponzoni, Milan (Italy)
15.00-15.30h Splenic B Lymphoma/leukemia unclassifiable (hairy variant and diffuse red pulp)
Estella Matutes, Barcelona (Spain)
15.30-16.00h Coffee
16.00-17.45h WORKSHOP 3
Impact of genetic alterations in the classification of lymphoproliferative neoplasms with villous lymphocytes and other small B cell lymphoproliferative neoplasms
(i.e indolent mantle cell lymphoma, lymphoplasmacytic lymphoma, splenic marginal zone lymphoma)

Chairs: Estella Matutes, Barcelona (Spain) and Fina Climent, Barcelona (Spain)

LPD-24 – MCL with atypical phenotype and molecular profile
Laura Bandiera, Milan (Italy)

LPD-31 – Lymphoplasmacytic lymphoma (Waldenstrom macroglobulinemia):
correlation of therapeutic response to genetic findings

Yen-Chun Liu, Pittsburgh (USA)

LPD-52 – Primary cold agglutinin disease
Roos Leguit, Utrecht (The Netherlands)

LPD-66 – Concurrent presentation of hairy cell leukemia and mantle cell lymphoma (leukemic non-nodal variant): and extremely rare composite lymphoma
Dina Soliman, Doha (Qatar)

LPD-73 – The thumbprint of TP53 dysfunction: loosening the grip of aberrant antigen expression to categorize indolent B-cell lymphoma
Fabienne Lucas, Boston (USA)

Session summary by the chairs

17.45-18.00h Concluding remarks, next EBMWG course
Alexandar Tzankov, Basel (Switzerland) and María Rozman, Barcelona (Spain)